Dr Jason Brown
- Lecturer in Oral Sciences (Dental School)
email:
Jason.Brown@glasgow.ac.uk
378 Sauchiehall Street (Level 8, office K12), Glasgow, Glasgow City, Scotland, United Kingdom, G2 3JZ
https://orcid.org/0000-0002-8168-5333Biography
Dr Jason L Brown graduated from Durham University with a BSc (hons) in Biomedical Sciences in 2014 before undertaking a research masters (MPhil) in Dental Microbiology at the University of Liverpool the following academic year. He completed his PhD jointly at the Universities of Glasgow and the West of Scotland in 2018 with a thesis entitled "Cellular Responses in Oral Health and Disease". Subsequently, he worked as a research assistant at the University of Glasgow Dental School in an industrially collaborative project with GlaxoSmithKline for 1.5 years and a National Biofilm Innovation Centre (NBIC) funded project for 0.5 years.
Jason became a research associate in 2021 on a Engineering and Physical Sciences Research Council (EPSRC) collaborative project with the Universities of Bath and Lancaster studying the potential use of plasma technology to combat wound-related biofilms. Jason became a lecturer in Oral Sciences in February 2022. He lectures on a wide range of courses, including the BDS, Nursing and Microbiology undergraduate courses, and plays a pivotal role in the running of the postgraduate taught Oral Sciences course at the University (https://www.gla.ac.uk/postgraduate/taught/oralsciences/), whilst also being a primary and secondary supervisor to various PhD students.
Externally, Dr Brown is a member of several societies including the European Society of Clinical Microbiology and Infectious Diseases, Society of Applied Microbiology and International Association of Dental Research. He is also a principal investigator for the Glasgow Biofilm Research Network and an associate editor for the Critical Reviews in Microbiology journal.
Research interests
Dr Brown has an extensive research background in bacterial, fungal and interkingdom biofilm models relating to different niches within the human body including the oral cavity and the skin. He is also interested in investigating host-pathogen interactions at these mucosal sites using simple and complex organotypic co-culture systems.
Publications
2023
Baz, A. et al. (2023) Staphylococcus aureus strains exhibit heterogenous tolerance to direct cold atmospheric plasma therapy. Biofilm, 5, 100123. (doi: 10.1016/j.bioflm.2023.100123) (PMID:37138646) (PMCID:PMC10149328)
Johnston, W., Ware, A., Kuiters, W. F., Delaney, C., Brown, J. L. , Hagen, S., Corcoran, D., Cummings, M., Ramage, G. and Kean, R. (2023) In vitro bacterial vaginosis biofilm community manipulation using endolysin therapy. Biofilm, 5, 100101. (doi: 10.1016/j.bioflm.2022.100101) (PMID:36655001) (PMCID:PMC9841237)
Delaney, C., Alapati, S., Alshehri, M., Kubalova, D., Veena, C. L. R., Abusrewil, S., Short, B., Bradshaw, D. and Brown, J. L. (2023) Investigating the role of Candida albicans as a universal substrate for oral bacteria using a transcriptomic approach: implications for interkingdom biofilm control? APMIS: Journal of Pathology, Microbiology and Immunology, 131(11), pp. 601-612. (doi: 10.1111/apm.13327) (PMID:37170476)
Short, B., Bakri, A., Baz, A., Williams, C., Brown, J. and Ramage, G. (2023) There is more to wounds than bacteria: fungal biofilms in chronic wounds. Current Clinical Microbiology Reports, 10(1), pp. 9-16. (doi: 10.1007/s40588-022-00187-x)
Malcolm, J. et al. (2023) C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, 102994. (doi: 10.1016/j.jaut.2023.102994) (PMID:36706535)
Brown, J. L. , Butcher, M. C., Ramalingam Veena, C. L., Chogule, S., Johnston, W. and Ramage, G. (2023) Generation of multispecies oral bacteria biofilm models. In: Seymour, G. J., Cullinan, M. P., Heng, N. C. K. and Cooper, P. R. (eds.) Oral Biology: Molecular Techniques and Applications. Series: Methods in Molecular Biology, 2588. Humana Press: New York, pp. 187-199. ISBN 9781071627792 (doi: 10.1007/978-1-0716-2780-8_12)
2022
Ramage, G. , Short, B., McKloud, E., Alshanta, O. A., Butcher, M., Mclean, W. and Brown, J. L. (2022) Clinical management of fungal biofilm infections. In: Richter, K. and Kragh, K. N. (eds.) Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Series: Springer series on biofilms (vol 11). Springer: Cham, pp. 441-465. ISBN 9783031109911 (doi: 10.1007/978-3-031-10992-8_17)
Abduljalil, H., Bakri, A., Albashaireh, K., Alshanta, O. A., Brown, J. L. , Sherry, L. , Kean, R., Nile, C. , McLean, W. and Ramage, G. (2022) Screening the Tocriscreen™ bioactive compound library in search for inhibitors of Candida biofilm formation. APMIS: Journal of Pathology, Microbiology and Immunology, 130(9), pp. 568-577. (doi: 10.1111/apm.13260) (PMID:35791082)
Gülmez, D., Brown, J. L. , Butcher, M. C., Delaney, C., Kean, R., Ramage, G. and Short, B. (2022) Investigating dual-species Candida auris and staphylococcal biofilm antiseptic challenge. Antibiotics, 11(7), 931. (doi: 10.3390/antibiotics11070931) (PMID:35884184) (PMCID:PMC9312070)
Brown, J. L. , Short, B., Ware, A., Sherry, L. , Kean, R. and Ramage, G. (2022) Cell viability assays for Candida auris. In: Lorenz, A. (ed.) Candida auris. Series: Methods in molecular biology (2517). Humana: New York, pp. 129-153. ISBN 9781071624166 (doi: 10.1007/978-1-0716-2417-3_10)
Brown, J. L. , Townsend, E., Short, R. D., Williams, C., Woodall, C., Nile, C. J. and Ramage, G. (2022) Assessing the inflammatory response to in vitro polymicrobial wound biofilms in a skin epidermis model. npj Biofilms and Microbiomes, 8, 19. (doi: 10.1038/s41522-022-00286-z) (PMID:35393409) (PMCID:PMC8991182)
Brown, J. L. , Young, T., McKloud, E., Butcher, M. C., Bradshaw, D., Pratten, J. R. and Ramage, G. (2022) An in vitro evaluation of denture cleansing regimens against a polymicrobial denture biofilm model. Antibiotics, 11(1), 113. (doi: 10.3390/antibiotics11010113) (PMID:35052990) (PMCID:PMC8772836)
Butcher, M. C., Brown, J. L. , Hansom, D., Wilson-Van Os, R., Delury, C., Laycock, P. A. and Ramage, G. (2022) Antifungal loaded calcium sulfate beads as a potential therapeutic in combating Candida auris. Antimicrobial Agents and Chemotherapy, 66(1), e01713-21. (doi: 10.1128/AAC.01713-21) (PMID:34694875) (PMCID:PMC8765289)
2021
Short, B., Delaney, C., McKloud, E., Brown, J. L. , Kean, R., Litherland, G. J., Williams, C., Martin, S. L., MacKay, W. G. and Ramage, G. (2021) Investigating the transcriptome of Candida albicans in a dual-species Staphylococcus aureus biofilm mode. Frontiers in Cellular and Infection Microbiology, 11, 791523. (doi: 10.3389/fcimb.2021.791523)
Abusrewil, S., Brown, J. L. , Delaney, C., Butcher, M. C., Tiba, M., Scott, J. A. , Ramage, G. and McLean, W. (2021) Chitosan enhances the anti-biofilm activity of biodentine against an interkingdom biofilm model. Antibiotics, 10(11), 1317. (doi: 10.3390/antibiotics10111317)
Śmiga, M., Smalley, J. W., Ślęzak, P., Brown, J. L. , Siemińska, K., Jenkins, R. E., Yates, E. A. and Olczak, T. (2021) Glycation of host proteins increases pathogenic potential of Porphyromonas gingivalis. International Journal of Molecular Sciences, 22(21), 12084. (doi: 10.3390/ijms222112084) (PMID:34769513) (PMCID:PMC8585099)
Butcher, M. C., Brown, J. L. , Hansom, D., Wilson-van Os, R., Delury, C., Laycock, P. A. and Ramage, G. (2021) Assessing the bioactive profile of anti-fungal loaded calcium sulfate against fungal biofilms. Antimicrobial Agents and Chemotherapy, 65(6), e02551-20. (doi: 10.1128/AAC.02551-20) (PMID:33753336)
Johnston, W., Rosier, B.T., Artacho, A., Paterson, M., Piela, K., Delaney, C., Brown, J.L. , Ramage, G. , Mira, A. and Culshaw, S. (2021) Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients. Scientific Reports, 11, 9796. (doi: 10.1038/s41598-021-89002-z) (PMID:33963212) (PMCID:PMC8105330)
2020
Young, T., Alshanta, O.-A., Kean, R., Bradshaw, D., Pratten, J., Williams, C., Woodall, C., Ramage, G. and Brown, J. L. (2020) Candida albicans as an essential “keystone” component within polymicrobial oral biofilm models? Microorganisms, 9(1), 59. (doi: 10.3390/microorganisms9010059) (PMID:33379333) (PMCID:PMC7823588)
Abusrewil, S., Brown, J. L. , Delaney, C. D., Butcher, M. C., Kean, R., Gamal, D., Scott, J. A., McLean, W. and Ramage, G. (2020) Filling the void: an optimized polymicrobial interkingdom biofilm model for assessing novel antimicrobial agents in endodontic infection. Microorganisms, 8(12), 1988. (doi: 10.3390/microorganisms8121988) (PMID:33327403) (PMCID:PMC7764896)
Salomão Arias, L., Butcher, M. C., Short, B., McKloud, E., Delaney, C., Kean, R., Monteiro, D. R., Williams, C., Ramage, G. and Brown, J. L. (2020) Chitosan ameliorates Candida auris virulence in a Galleria mellonella infection model. Antimicrobial Agents and Chemotherapy, 64(8), e00476-20. (doi: 10.1128/AAC.00476-20) (PMID:32482674) (PMCID:PMC7526850)
Brown, J. L. , Delaney, C., Short, B., Butcher, M. C., McKloud, E., Williams, C., Kean, R. and Ramage, G. (2020) Candida auris phenotypic heterogeneity determines pathogenicity in vitro. mSphere, 5(3), e00371-20. (doi: 10.1128/mSphere.00371-20) (PMID:32581078) (PMCID:PMC7316489)
Kean, R., Brown, J. , Gulmez, D., Ware, A. and Ramage, G. (2020) Candida auris: a decade of understanding of an enigmatic pathogenic yeast. Journal of Fungi, 6(1), 30. (doi: 10.3390/jof6010030) (PMID:32110970)
Arias, L. S., Brown, J. L. , Butcher, M. C., Delaney, C., Monteiro, D. R. and Ramage, G. (2020) A nanocarrier system that potentiates the effect of miconazole within different interkingdom biofilms. Journal of Oral Microbiology, 12(1), 1771071. (doi: 10.1080/20002297.2020.1771071) (PMID:32922677) (PMCID:PMC7448886)
2019
Delaney, C. et al. (2019) Interkingdom interactions on the denture surface: implications for oral hygiene. Biofilm, 1, 100002. (doi: 10.1016/j.bioflm.2019.100002) (PMID:32201858) (PMCID:PMC7067236)
Brown, J. L. , Johnston, W., Delaney, C., Short, B., Butcher, M. C., Young, T., Butcher, J., Riggio, M. , Culshaw, S. and Ramage, G. (2019) Polymicrobial oral biofilm models: simplifying the complex. Journal of Medical Microbiology, 68(11), pp. 1573-1584. (doi: 10.1099/jmm.0.001063) (PMID:31524581)
Short, B., Brown, J. , Delaney, C., Sherry, L. , Williams, C., Ramage, G. and Kean, R. (2019) Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence. Journal of Hospital Infection, 103(1), pp. 92-96. 31226270. (doi: 10.1016/j.jhin.2019.06.006)
Brown, J. L. , Johnston, W., Delaney, C., Rajendran, R., Butcher, J., Khan, S., Bradshaw, D., Ramage, G. and Culshaw, S. (2019) Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells. Scientific Reports, 9, 15779. (doi: 10.1038/s41598-019-52115-7) (PMID:31673005) (PMCID:PMC6823452)
2018
Brown, J.L. , Campbell, L., Malcolm, J. , Adrados Planell, A., Butcher, J.P. and Culshaw, S. (2018) Enrichment of innate lymphoid cell populations in gingival tissue. Journal of Dental Research, 97(12), pp. 1399-1405. (doi: 10.1177/0022034518782141) (PMID:29928824)
Brown, J.L. , Yates, E.A., Bielecki, M., Olczak, T. and Smalley, J.W. (2018) Potential role for Streptococcus gordonii-derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis. Molecular Oral Microbiology, 33(4), pp. 322-335. (doi: 10.1111/omi.12229) (PMID:29847019)
Articles
Baz, A. et al. (2023) Staphylococcus aureus strains exhibit heterogenous tolerance to direct cold atmospheric plasma therapy. Biofilm, 5, 100123. (doi: 10.1016/j.bioflm.2023.100123) (PMID:37138646) (PMCID:PMC10149328)
Johnston, W., Ware, A., Kuiters, W. F., Delaney, C., Brown, J. L. , Hagen, S., Corcoran, D., Cummings, M., Ramage, G. and Kean, R. (2023) In vitro bacterial vaginosis biofilm community manipulation using endolysin therapy. Biofilm, 5, 100101. (doi: 10.1016/j.bioflm.2022.100101) (PMID:36655001) (PMCID:PMC9841237)
Delaney, C., Alapati, S., Alshehri, M., Kubalova, D., Veena, C. L. R., Abusrewil, S., Short, B., Bradshaw, D. and Brown, J. L. (2023) Investigating the role of Candida albicans as a universal substrate for oral bacteria using a transcriptomic approach: implications for interkingdom biofilm control? APMIS: Journal of Pathology, Microbiology and Immunology, 131(11), pp. 601-612. (doi: 10.1111/apm.13327) (PMID:37170476)
Short, B., Bakri, A., Baz, A., Williams, C., Brown, J. and Ramage, G. (2023) There is more to wounds than bacteria: fungal biofilms in chronic wounds. Current Clinical Microbiology Reports, 10(1), pp. 9-16. (doi: 10.1007/s40588-022-00187-x)
Malcolm, J. et al. (2023) C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, 102994. (doi: 10.1016/j.jaut.2023.102994) (PMID:36706535)
Abduljalil, H., Bakri, A., Albashaireh, K., Alshanta, O. A., Brown, J. L. , Sherry, L. , Kean, R., Nile, C. , McLean, W. and Ramage, G. (2022) Screening the Tocriscreen™ bioactive compound library in search for inhibitors of Candida biofilm formation. APMIS: Journal of Pathology, Microbiology and Immunology, 130(9), pp. 568-577. (doi: 10.1111/apm.13260) (PMID:35791082)
Gülmez, D., Brown, J. L. , Butcher, M. C., Delaney, C., Kean, R., Ramage, G. and Short, B. (2022) Investigating dual-species Candida auris and staphylococcal biofilm antiseptic challenge. Antibiotics, 11(7), 931. (doi: 10.3390/antibiotics11070931) (PMID:35884184) (PMCID:PMC9312070)
Brown, J. L. , Townsend, E., Short, R. D., Williams, C., Woodall, C., Nile, C. J. and Ramage, G. (2022) Assessing the inflammatory response to in vitro polymicrobial wound biofilms in a skin epidermis model. npj Biofilms and Microbiomes, 8, 19. (doi: 10.1038/s41522-022-00286-z) (PMID:35393409) (PMCID:PMC8991182)
Brown, J. L. , Young, T., McKloud, E., Butcher, M. C., Bradshaw, D., Pratten, J. R. and Ramage, G. (2022) An in vitro evaluation of denture cleansing regimens against a polymicrobial denture biofilm model. Antibiotics, 11(1), 113. (doi: 10.3390/antibiotics11010113) (PMID:35052990) (PMCID:PMC8772836)
Butcher, M. C., Brown, J. L. , Hansom, D., Wilson-Van Os, R., Delury, C., Laycock, P. A. and Ramage, G. (2022) Antifungal loaded calcium sulfate beads as a potential therapeutic in combating Candida auris. Antimicrobial Agents and Chemotherapy, 66(1), e01713-21. (doi: 10.1128/AAC.01713-21) (PMID:34694875) (PMCID:PMC8765289)
Short, B., Delaney, C., McKloud, E., Brown, J. L. , Kean, R., Litherland, G. J., Williams, C., Martin, S. L., MacKay, W. G. and Ramage, G. (2021) Investigating the transcriptome of Candida albicans in a dual-species Staphylococcus aureus biofilm mode. Frontiers in Cellular and Infection Microbiology, 11, 791523. (doi: 10.3389/fcimb.2021.791523)
Abusrewil, S., Brown, J. L. , Delaney, C., Butcher, M. C., Tiba, M., Scott, J. A. , Ramage, G. and McLean, W. (2021) Chitosan enhances the anti-biofilm activity of biodentine against an interkingdom biofilm model. Antibiotics, 10(11), 1317. (doi: 10.3390/antibiotics10111317)
Śmiga, M., Smalley, J. W., Ślęzak, P., Brown, J. L. , Siemińska, K., Jenkins, R. E., Yates, E. A. and Olczak, T. (2021) Glycation of host proteins increases pathogenic potential of Porphyromonas gingivalis. International Journal of Molecular Sciences, 22(21), 12084. (doi: 10.3390/ijms222112084) (PMID:34769513) (PMCID:PMC8585099)
Butcher, M. C., Brown, J. L. , Hansom, D., Wilson-van Os, R., Delury, C., Laycock, P. A. and Ramage, G. (2021) Assessing the bioactive profile of anti-fungal loaded calcium sulfate against fungal biofilms. Antimicrobial Agents and Chemotherapy, 65(6), e02551-20. (doi: 10.1128/AAC.02551-20) (PMID:33753336)
Johnston, W., Rosier, B.T., Artacho, A., Paterson, M., Piela, K., Delaney, C., Brown, J.L. , Ramage, G. , Mira, A. and Culshaw, S. (2021) Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients. Scientific Reports, 11, 9796. (doi: 10.1038/s41598-021-89002-z) (PMID:33963212) (PMCID:PMC8105330)
Young, T., Alshanta, O.-A., Kean, R., Bradshaw, D., Pratten, J., Williams, C., Woodall, C., Ramage, G. and Brown, J. L. (2020) Candida albicans as an essential “keystone” component within polymicrobial oral biofilm models? Microorganisms, 9(1), 59. (doi: 10.3390/microorganisms9010059) (PMID:33379333) (PMCID:PMC7823588)
Abusrewil, S., Brown, J. L. , Delaney, C. D., Butcher, M. C., Kean, R., Gamal, D., Scott, J. A., McLean, W. and Ramage, G. (2020) Filling the void: an optimized polymicrobial interkingdom biofilm model for assessing novel antimicrobial agents in endodontic infection. Microorganisms, 8(12), 1988. (doi: 10.3390/microorganisms8121988) (PMID:33327403) (PMCID:PMC7764896)
Salomão Arias, L., Butcher, M. C., Short, B., McKloud, E., Delaney, C., Kean, R., Monteiro, D. R., Williams, C., Ramage, G. and Brown, J. L. (2020) Chitosan ameliorates Candida auris virulence in a Galleria mellonella infection model. Antimicrobial Agents and Chemotherapy, 64(8), e00476-20. (doi: 10.1128/AAC.00476-20) (PMID:32482674) (PMCID:PMC7526850)
Brown, J. L. , Delaney, C., Short, B., Butcher, M. C., McKloud, E., Williams, C., Kean, R. and Ramage, G. (2020) Candida auris phenotypic heterogeneity determines pathogenicity in vitro. mSphere, 5(3), e00371-20. (doi: 10.1128/mSphere.00371-20) (PMID:32581078) (PMCID:PMC7316489)
Kean, R., Brown, J. , Gulmez, D., Ware, A. and Ramage, G. (2020) Candida auris: a decade of understanding of an enigmatic pathogenic yeast. Journal of Fungi, 6(1), 30. (doi: 10.3390/jof6010030) (PMID:32110970)
Arias, L. S., Brown, J. L. , Butcher, M. C., Delaney, C., Monteiro, D. R. and Ramage, G. (2020) A nanocarrier system that potentiates the effect of miconazole within different interkingdom biofilms. Journal of Oral Microbiology, 12(1), 1771071. (doi: 10.1080/20002297.2020.1771071) (PMID:32922677) (PMCID:PMC7448886)
Delaney, C. et al. (2019) Interkingdom interactions on the denture surface: implications for oral hygiene. Biofilm, 1, 100002. (doi: 10.1016/j.bioflm.2019.100002) (PMID:32201858) (PMCID:PMC7067236)
Brown, J. L. , Johnston, W., Delaney, C., Short, B., Butcher, M. C., Young, T., Butcher, J., Riggio, M. , Culshaw, S. and Ramage, G. (2019) Polymicrobial oral biofilm models: simplifying the complex. Journal of Medical Microbiology, 68(11), pp. 1573-1584. (doi: 10.1099/jmm.0.001063) (PMID:31524581)
Short, B., Brown, J. , Delaney, C., Sherry, L. , Williams, C., Ramage, G. and Kean, R. (2019) Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence. Journal of Hospital Infection, 103(1), pp. 92-96. 31226270. (doi: 10.1016/j.jhin.2019.06.006)
Brown, J. L. , Johnston, W., Delaney, C., Rajendran, R., Butcher, J., Khan, S., Bradshaw, D., Ramage, G. and Culshaw, S. (2019) Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells. Scientific Reports, 9, 15779. (doi: 10.1038/s41598-019-52115-7) (PMID:31673005) (PMCID:PMC6823452)
Brown, J.L. , Campbell, L., Malcolm, J. , Adrados Planell, A., Butcher, J.P. and Culshaw, S. (2018) Enrichment of innate lymphoid cell populations in gingival tissue. Journal of Dental Research, 97(12), pp. 1399-1405. (doi: 10.1177/0022034518782141) (PMID:29928824)
Brown, J.L. , Yates, E.A., Bielecki, M., Olczak, T. and Smalley, J.W. (2018) Potential role for Streptococcus gordonii-derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis. Molecular Oral Microbiology, 33(4), pp. 322-335. (doi: 10.1111/omi.12229) (PMID:29847019)
Book Sections
Brown, J. L. , Butcher, M. C., Ramalingam Veena, C. L., Chogule, S., Johnston, W. and Ramage, G. (2023) Generation of multispecies oral bacteria biofilm models. In: Seymour, G. J., Cullinan, M. P., Heng, N. C. K. and Cooper, P. R. (eds.) Oral Biology: Molecular Techniques and Applications. Series: Methods in Molecular Biology, 2588. Humana Press: New York, pp. 187-199. ISBN 9781071627792 (doi: 10.1007/978-1-0716-2780-8_12)
Ramage, G. , Short, B., McKloud, E., Alshanta, O. A., Butcher, M., Mclean, W. and Brown, J. L. (2022) Clinical management of fungal biofilm infections. In: Richter, K. and Kragh, K. N. (eds.) Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Series: Springer series on biofilms (vol 11). Springer: Cham, pp. 441-465. ISBN 9783031109911 (doi: 10.1007/978-3-031-10992-8_17)
Brown, J. L. , Short, B., Ware, A., Sherry, L. , Kean, R. and Ramage, G. (2022) Cell viability assays for Candida auris. In: Lorenz, A. (ed.) Candida auris. Series: Methods in molecular biology (2517). Humana: New York, pp. 129-153. ISBN 9781071624166 (doi: 10.1007/978-1-0716-2417-3_10)
